An Uncommon Complication of Emphysematous Cystitis and Pyelitis.

Psoas muscle abscesses associated with emphysematous urinary tract infections are rare. There are not many case reports about urinary tract infections such as emphysematous pyelitis and emphysematous cystitis complicating psoas muscle abscesses. Here, we report a case of an ipsilateral psoas muscle abscess following emphysematous cystitis and emphysematous pyelitis in an 81-year-old diabetic man. He was treated with prolonged antibiotic therapy and other supportive care.

Pielitis incrustante en varón con derivación urinaria tipo bricker portador de catéter ureteral / Encrusted pyelitis in a man with bricker type urinary diversion ureteral catheter carrier

Objetivo: La pielitis incrustante es una infección causada por Corynebacterium Urealyticum cuya incidencia está aumentando, sobre todo en pacientes inmunodeprimidos, y en portadores de catéteres permanentes.Método: Se presenta el caso de un varón de 72 añoscon derivación urinaria tipo Bricker y portador de catéter JJ. Posteriormente se objetiva calcificación del mismocon imágenes en la TAC sugestivas de pielitis incrustantey urocultivos positivos para Corynebacterium Urealyticum.Se realiza tratamiento combinado endoscópico y médicocon antibioterapia y acidificación de la orina, a través denefrostomía con solución acidificante de irrigación y porvía oral con Lit-Control pH Down, para evitar nuevas infecciones.Resultados: El tratamiento fue efectivo, con ausencia dereinfecciones gracias al tratamiento de mantenimiento conLit-Control pH Down. Conclusiones: La sospecha diagnóstica y tratamientoprecoz de la pielitis incrustante evitan las complicacionesasociadas. La antibioterapia asociada a acidificación dela orina son los pilares básicos de tratamiento.

Objetive: Encrusted pyelitis in an infectioncaused by Corynebacterium Urealyticum. The incidencehas increased, specially in immunosuppressed patients andpatients with indwelling urinary catheters.Methods: We are presenting a case of a 72 yearsold male with Bricker urinary derivation with an ureteralcatheter. During the follow up, catheteral calcification andencrusted pyelitis were found in TC images and cultureswere positive for Corynebacteirum Urealitycum. This condition was managed with endoscopic and medical treatment; that consisted in antibiotics and acidification of urinethrough nephrostomy tube using an acidifying irrigationsolution and Lit-Control pH Down orally, in order to avoidnew infections.Results: Treatment was effective, no new reinfectionswere shown with the use of Lit-Control pH Down for themaintenance.Conclusions: The suspected diagnosis and the earlytreatment of encrusted pyelitis avoid complications. Antibiotics and urine acidification are key in the treatment of thisdisease.(AU)

Encrusted pyelitis in a male with bricker urinary derivation and ureteral catheter.

OBJECTIVE: Encrusted pyelitis in an infection caused by Corynebacterium Urealyticum. The incidence has increased, specially in immunosuppressed patients and patients with indwelling urinary catheters. METHODS: We are presenting a case of a 72 years old male with Bricker urinary derivation with an ureteral catheter. During the follow up, catheteral calcification and encrusted pyelitis were found in TC images and cultures were positive for Corynebacteirum Urealitycum. This condition was managed with endoscopic and medical treatment; that consisted in antibiotics and acidification of urine through nephrostomy tube using an acidifying irrigation solution and Lit-Control pH Down orally, in order to avoid new infections. RESULTS: Treatment was effective, no new reinfections were shown with the use of Lit-Control pH Down for the maintenance. CONCLUSIONS: The suspected diagnosis and the early treatment of encrusted pyelitis avoid complications. Antibiotics and urine acidification are key in the treatment of this disease.

OBJETIVO: La pielitis incrustante es una infección causada por Corynebacterium Urealyticum cuya incidencia está aumentando, sobre todo en pacientes inmunodeprimidos, y en portadores de catéteres permanentes.MÉTODOS: Se presenta el caso de un varón de 72 años con derivación urinaria tipo Bricker y portador de catéter JJ. Posteriormente se objetiva calcificación del mismo con imágenes en la TAC sugestivas de pielitis incrustante y urocultivos positivos para Corynebacterium Urealyticum. Se realiza tratamiento combinado endoscópico y médico con antibioterapia y acidificación de la orina, a través de nefrostomía con solución acidificante de irrigación y por vía oral con Lit-Control pH Down, para evitar nuevas infecciones. RESULTADOS: El tratamiento fue efectivo, con ausencia de reinfecciones gracias al tratamiento de mantenimiento con Lit-Control pH Down. CONCLUSIONES: La sospecha diagnóstica y tratamiento precoz de la pielitis incrustante evitan las complicaciones asociadas. La antibioterapia asociada a acidificación de la orina son los pilares básicos de tratamiento.

A case of ureteral fungal mass removal in a patient taking empagliflozin.

With increased use of sodium-glucose co-transporter 2 (SGLT2) inhibitors as antidiabetic agents, the risk of serious fungal urinary tract infection (UTI) may be increased. We present the case of a 67-year-old Caucasian female who was admitted for emphysematous pyelitis and found to have a fungal ball in the renal pelvis. Candida glabrata was cultured and the patient was managed with percutaneous nephrostomy tube placement and antifungal treatment. The fungal ball persisted and required surgical removal with ureteroscopy and basket extraction. Fungal balls can be a difficult sequelae of UTIs requiring a combination of antifungal and surgical intervention for definitive management.

Gas Where It Shouldn't Be! Imaging Spectrum of Emphysematous Infections in the Abdomen and Pelvis.

OBJECTIVE. The purpose of this article is to review the spectrum, etiopathogenesis, clinical presentation, imaging features, differential diagnoses, and management of emphysematous infections of the abdomen and pelvis. CONCLUSION. Emphysematous infections are associated with high morbidity and mortality and thus need urgent medical and surgical interventions. CT is the most sensitive modality to detect gas; CT provides definitive diagnosis in most cases and can depict the extent of involvement.

Asymptomatic emphysematous pyelitis-a rare clinical entity.

A 62-year-old asymptomatic woman with diabetes was referred to the urology department from nephrology due to deterioration in renal function with accompanied right-sided hydronephrosis on ultrasound. CT imaging subsequently revealed a right-sided staghorn calculus and a significant volume of gas in the right collecting system from the kidney to the distal ureter, in keeping with emphysematous pyelitis. She was admitted and managed with antibiotics and insertion of right nephrostomy in the first instance, followed by percutaneous nephrolithotomy to definitively manage the stone. The patient remained asymptomatic throughout the process.

Gas in the kidney in asymptomatic Escherichia coli urinary tract infections in a patient with severe vesicoureteral reflex.

Diabetes mellitus (DM) is a common disease in Oman as in rest of Gulf Cooperation Council where metabolic syndrome is of high prevalence. DM is a foremost risk factor for urinary tract infections (UTIs). It is also linked to more complicated infections such as emphysematous pyelonephritis (EPN), emphysematous pyelitis (EP), renal/perirenal abscess, emphysematous cystitis, xanthogranulomatous pyelonephritis, and renal papillary necrosis. The diagnosis of these cases is frequently delayed because the clinical manifestations are generic and not different from the typical triad of upper UTI, which include fever, flank pain, and pyuria. A middle-aged female with DM and chronic kidney disease stage IV was admitted with recurrent UTI with extended-spectrum beta-lactamase-producing Escherichia coli. At presentation, she was afebrile, clinically stable, had no flank pain and there was no leukocytosis. Laboratory test for C- reactive protein done twice and was only mildly elevated at 7 and 11 mg/dL. A computed tomography scan of kidney-ureter-bladder (CT-KUB) was recommended and reported as "no KUB stone but small atrophic left kidney with dilatation of the pelvicalycial system and ureter and the presence of air in the collecting system suggestive of EP." Thus, commonly associated with DM, especially in females, debilitated immune-deficient individuals, and patients harboring obstructed urinary system with infective nidus. Air in the kidney is not always due to EPN. UTI with a gas-producing organism can ascend to the kidney in the presence of vesicoureteral reflux.

Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis / 소아과

Acute pyelonephritis (APN) should be detected and treated as soon as possible to reduce the risk of the development of acquired renal scarring. However, in the medical field, urine culture results are not available or considered when the prompt discrimination of APN is necessary and empirical treatment is started. Furthermore, urine culture cannot discriminate APN among children with febrile urinary tract infection (UTI) (pyelitis, lower UTI with other fever focus). Therefore, the usefulness of urine culture for diagnostic purposes is small and the sampling procedure is invasive. Congenital hypoplastic kidney is the most common cause of chronic kidney injury in children. Thus, it is desirable that a main target be detected as early as possible when imaging studies are performed in children with APN. However, if APN does not recur, no medical or surgical treatment or imaging studies would be needed because the acquired renal scar would not progress further. Therefore, the long-term prognosis of APN in young children, particularly infants, depends on the number of recurrent APN, not other febrile UTI. New methods that enable prompt, practical, and comfortable APN diagnosis in children are needed as alternatives to urinary catheterization for urine culture sampling.

[Encrusted Pyelitis during a case of Thrombotic Thrombocytopenic Purpura].

Encrusted pyelitis is a chronic urinary tract infection associated with mucosal encrustation induced by urea splitting bacteria. More than 40 bacteria have been implicated but the most frequent is Corynebacterium group D2. Predisposing factors are debilitating chronic diseases and preexisting urological procedures. Immunosoppression is an important cofactor. For these reasons the disease is almost always nosocomially acquired and renal transplant recipients are at particular risk. The symptoms are not specific and long lasting: dysuria, flank pain and gross haematuria are the most frequent; fever is present in two-thirds. The demonstration of urine splitting bacteria in constantly alkaline urines and radiological evidence of extensive calcification of pelvicalyceal system, ureter and bladder at US or CT scan in a clinical context of predisposing factors are the mainstay of diagnosis. Treatment is based on adapted antibiotic therapy, acidification of urine and excision of plaques of calcified encrustation. The prognosis relies on timing of diagnosis; delay can be detrimental and result in patient's death and graft loss. We describe a unique case of 69-year-old man with two contemporary diseases: autoimmune thrombotic thrombocytopenic purpura and encrusted pyelitis with a fatal evolution.

Pseudotuberculous Granulomatous Pyelitis.

We report a case of pseudotuberculous granulomatous pyelitis in an elderly female patient with hydronephrotic right kidney secondary to obstructing urinary stone. Pseudotuberculous granulomatous pyelitis is a rarely reported entity, characterized by severe granulomatous inflammation limited predominantly to the renal pelvis. It is associated with urinary (pelvicalyceal) obstruction, urolithiasis well as non- Mycobacterial urinary tract infection.

Corynebacterium urealyticum: aumento de la incidencia de infección y uropatía incrustante / Corinebacterium urealyticum: increased incidence of infection and encrusted uropathy

Introducción: Corynebacterium urealyticum (CU) afecta a pacientes inmunodeprimidos, crónicos o multioperados. La uropatía incrustante (UI) representa una complicación de la infección. Objetivo del estudio: demostrar el aumento creciente de casos de infección por CU y UI en los últimos 5 años. Material y métodos: Estudio descriptivo de pacientes urológicos con urocultivo positivo a CU (enero de 2009-diciembre de 2014). Cálculo de distribución anual y características clínicas de infección por CU y UI. Seguimiento mínimo: 6 meses. Obtención de medias y rangos estadísticos de parámetros clínicos pre/postratamiento. Resultados: Total de pacientes con CU: 115 (hombres 87: mujeres 28). Edad: 67,9 años (rango 6-95). Distribución anual (casos) 2009: 9 (7,8%), 2010: 13 (11,3%), 2011: 9 (7,8%), 2012: 20 (17,4%), 2013: 31 (27%), 2014: 33 (28,7%). Incremento 2009-2014: 300%. Cirugía urológica múltiple: 89 casos (77,3%). Complicaciones quirúrgicas: 77 casos (66,9%). Pacientes con UI: 18 casos (15,6%) (hombres 13: mujeres 5): pielitis 12 (66,7%), cistopatía 3 (16,6%), prostatic capsule disease 2 (11,2%), calcificación de la malla uno (5,5%). Análisis de 18 casos con UI: PH orina pre/postantibiótico: 8 (r = 6-9) vs 6 (r = 5-7). Cultivo negativo postantibiótico: 100%. Aplicación de solución acidificante: 5 casos. Cirugía: 13 casos (72,2%). Resultados pre/postratamiento multimodal: insuficiencia renal: 12 (66,6%) vs 9 (50%), filtrado glomerular (FG): 45,8 (r = 6- > 90) vs 52,7 (r = 13- > 90). Mejoría del FG: 6,94 puntos (T Wilcoxon p = 0,102). Radiología (incrustaciones): mejoría 13 (72,2%), igual 5 (27,8%). No mortalidad específica por CU. Conclusiones: La prevalencia de infección por CU y la UI está aumentando. El tratamiento antibiótico es muy eficaz. Las soluciones acidificantes son una opción aceptable para reducir calcificaciones

Introduction: Corynebacterium urealyticum (CU) affects patients who are immunosuppressed, chronically ill or have undergone numerous operations. Obstructive uropathy (OU) is a complication of infection. Study objective: To demonstrate the growing increase in cases of infection by CU and OU in the past 5 years. Material and methods: A descriptive study was conducted of urological patients with CU-positive urine cultures (January 2009-December 2014). We calculated the annual distribution and clinical characteristics of infection by CU and OU. Minimum follow-up: 6 months. We obtained the statistical means and ranges of clinical parameters pre/post-therapy. Results: The total number of patients with CU was 115 (men, 87; women, 28). The mean age was 67.9 years (range, 6-95 years), and the annual distribution of cases for 2009, 2010, 2011, 2012, 2013 and 2014 was 9 (7.8%), 13 (11.3%), 9 (7.8%), 20 (17.4%), 31 (27%) and 33 (28.7%), respectively. The increase in cases for 2009-2014 was 300%. Multiple urological surgeries were performed in 89 cases (77.3%), with surgical complications in 77 cases (66.9%). Eighteen (15.6%) patients had OU (men, 13; women, 5), 12 had pyelitis (66.7%), 3 had cystopathy (16.6%), 2 had prostatic capsule disease (11.2%) and 1 had mesh calcification (5.5%). The analysis of the 18 cases with OU showed pre/postantibiotic therapy urine pHs of 8 (r, 6-9) vs. 6 (r, 5-7). All postantibiotic cultures were negative. Acidifying solution was applied in 5 cases, and surgery was performed in 13 cases (72.2%). The results from before/after the multimodal therapy showed renal impairment in 12 (66.6%) vs. 9 cases (50%) and glomerular filtration rates (GFR) of 45.8 (r, 6- > 90) vs. 52.7 (r, 13- > 90). The improvement in GFR was 6.94 points (T Wilcoxon; P = .102). The radiology results (incrustations) showed improvement in 13 patients (72.2%) and no change in 5 (27.8%). There was no specific mortality for CU. Conclusions: The prevalence of infection by CU and OU is increasing. Antibiotic treatment is highly effective. Acidifying solutions are an acceptable option for reducing calcifications

Cistitis enfisematosa: 2 casos con diferente evolución / Emphysematous cystitis: Report of 2 cases with different outcomes

OBJETIVO: Reportar dos nuevos casos de cistitis enfisematosa, una patología poco frecuente pero potencialmente grave. MÉTODO: Análisis de dos casos tratados en nuestro centro de diferente forma y revisión de la literatura. RESULTADO: El primer paciente dado lo avanzado del caso tuvo que ser sometido a una cistectomía radical urgente; el segundo, se benefició de un tratamiento conservador y novedoso, al ser sometido a dos sesiones de oxigenoterapia hiperbárica. CONCLUSIONES: Es importante un diagnóstico precoz de esta patología. La oxigenoterapia hiperbárica puede ser beneficiosa debido a la mejora en la oxigenación de los tejidos afectos por la enfermedad

OBJECTIVE: To report two cases of emphysematous cystitis, a rare, potentially serious disease. METHODS: Analysis of two different cases treated in our center and review of the existing literature. RESULTS: One patient underwent emergency surgery (radical cystectomy) due to the advanced stage of the disease. The second patient, whose was in an initial stage, benefited from a new treatment, consisting of hyperbaric oxygen and wide spectrum antibiotics. CONCLUSIONS: Early diagnosis is the cornerstone of the conservative management of the disease. Hyperbaric oxygen therapy may be beneficial due to the improvement in oxygenation of the tissues affected by the disease